Clemizole Hydrochloride
Clemizole hydrochloride is known as a potent TRPC5 channel blocker and as the agent having some, though very small, impact on TRPM3, TRPM8 and TRPV1-4 channels. It is widely used in treatment of the Dravet syndrome due to his anticonvulsant effect.
Besides, this substance is applicable to cure the pruritic skin disorders and to relief of the allergic conditions as a strong antagonist of H1 histamine receptor. It may also be applied topically as the undecylenate derivatives, the sodium sulfate and the hexachlorophene along with local anesthetics and corticosteroids. Though, there may be a risk of sensitization.
The recent studies proved clemizole hydrochloride to be beneficial in the treatment of hepatitis C virus especially in combination with HCV protease inhibitors.
Chemical Properties
The substance is soluble in water. In order to increase the solubility it is recommended to warm the agent at 37 ℃ and shake it in the ultrasonic bath for some time. The container with clemizole hydrochloride should be kept tightly closed in well-ventilated and dry place. The recommended storage temperature is -20oC. It is advisable to ship the substance with RT or blue ice.
Safety Recommendations
Clemizole hydrochloride is characterized with acute toxicity. For safe handling one need to avoid direct contact with eyes and skin, as well as to provide the proper ventilation in place where dust may be formed. It is recommended to wear respiratory protection and immediately go into the fresh air if inhaled some. You should not eat, drink or smoke when working with the product.
After skin or eye contact, wash with ample amount of water. Remove the contact lenses if any and assure accurate flushing by separating the eyelids with fingers. If swallowed, rinse the mouth and call a poison center or a doctor.
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